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  • Title: Residual water suppression by indirect covariance NMR.
    Author: Chen Y, Zhang F, Brüschweiler R.
    Journal: Magn Reson Chem; 2007 Nov; 45(11):925-8. PubMed ID: 17876854.
    Abstract:
    Residual water solvent signals in 2D NMR experiments adversely affect appearance and subsequent analysis of spectra. A method for water suppression that is based on indirect covariance processing is described. It produces a symmetric spectrum with a water signal that is substantially decreased or completely absent. The method, which can be combined with other water suppression schemes, is demonstrated for 2D TOCSY, NOESY, and ROESY spectra of the protein, ubiquitin in aqueous solution.
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