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  • Title: The use of low-dose warfarin as prophylaxis for central venous catheter thrombosis in patients with cancer: a meta-analysis.
    Author: Rawson KM, Newburn-Cook CV.
    Journal: Oncol Nurs Forum; 2007 Sep; 34(5):1037-43. PubMed ID: 17878131.
    Abstract:
    PURPOSE/OBJECTIVES: To determine whether the use of low-dose warfarin could reduce the incidence of thrombosis in patients with cancer who have a central venous catheter (CVC). DATA SOURCES: MEDLINE, CINAHL, CANCERLIT, EMBASE, and the Cochrane Library. DATA SYNTHESIS: Meta-analysis of four studies (N = 1,236 patients) revealed that 6.4% of warfarin-treated patients experienced a thrombotic event compared with 7.5% in the control (no treatment) group. The risk difference for thrombus formation was not significant (2.0%, confidence interval = -9.0% to 5.0%). CONCLUSIONS: The administration of warfarin did not reduce the incidence of symptomatic or asymptomatic CVC-associated thrombosis in patients with cancer. IMPLICATIONS FOR NURSING: Using research findings to inform clinical nursing practice is important in caring for patients and providing optimal and improved patient outcomes. Prophylactic use of low-dose warfarin may not prevent thrombus formation and is associated with potentially adverse patient outcomes.
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