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  • Title: Anthecularin: a novel sesquiterpene lactone from Anthemis auriculata with antiprotozoal activity.
    Author: Karioti A, Skaltsa H, Linden A, Perozzo R, Brun R, Tasdemir D.
    Journal: J Org Chem; 2007 Oct 12; 72(21):8103-6. PubMed ID: 17880246.
    Abstract:
    Anthecularin (1), a minor sesquiterpene lactone with a novel ring system was isolated from Greek Anthemis auriculata (Asteraceae). Its structure was elucidated by means of NMR, HRMS, and X-ray crystallography. Anthecularin showed antitrypanosomal (IC50=10.1 microg/mL) and antiplasmodial activity (IC50=23.3 microg/mL) and inhibited two key enzymes of the plasmodial type II fatty acid biosynthesis pathway, PfFabI and PfFabG (IC50 values=14 and 28.3 microg/mL, respectively). A probable biogenesis of 1 is also proposed and discussed.
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