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  • Title: The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease.
    Author: Kalinderi K, Fidani L, Bostantjopoulou S, Katsarou Z, Kotsis A.
    Journal: Eur J Neurol; 2007 Oct; 14(10):1088-90. PubMed ID: 17880562.
    Abstract:
    Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 2% of the population >60 years of age. Although, the etiology of PD is still unknown, the genetic background of the disease has been documented. Recently, a mutation in the LRRK2 gene, G2019S, was associated with 3-41% and 1-2% of familial and sporadic PD, respectively suggesting a pivotal role of LRRK2 in PD. In this report, we examine the association of the G2019S mutation with sporadic late-onset PD, in an independent cohort of Greek patients and controls.
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