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  • Title: Molecular and epidemiological trend of norovirus associated gastroenteritis in Dhaka City, Bangladesh.
    Author: Dey SK, Nguyen TA, Phan TG, Nishio O, Salim AF, Rahman M, Yagyu F, Okitsu S, Ushijima H.
    Journal: J Clin Virol; 2007 Nov; 40(3):218-23. PubMed ID: 17881286.
    Abstract:
    BACKGROUND: Diarrhea, over the years, has killed millions of people and continues to be a major threat in Bangladesh. OBJECTIVES: To determine the incidence of norovirus infection in infants and young children with acute gastroenteritis in Dhaka City, Bangladesh and to determine the genogroup and genotype in norovirus-positive stool specimens. STUDY DESIGN: Fecal specimens were collected from infants and children with acute gastroenteritis in Dhaka City, Bangladesh from October 2004 to September 2005, and examined for norovirus by reverse transcription-polymerase chain reaction. RESULTS: Noroviruses were detected in 41 of 917 fecal specimens. Molecular analysis of norovirus was carried out by sequencing methods. Only norovirus GII/4 strains were detected during this study. The dominant genotype throughout the study period was GII/4. Norovirus infections were most commonly observed in winter and rainy seasons in Dhaka City. The common clinical symptoms in norovirus-infected patients were diarrhea (90%), vomiting (75%) and abdominal pain (46%). CONCLUSIONS: This is the first epidemiological research of norovirus in Bangladesh. Norovirus is an important enteropathogen responsible for viral gastroenteritis among infants and children in Bangladesh.
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