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  • Title: Confirmation of cannabinoids in meconium using two-dimensional gas chromatography with mass spectrometry detection.
    Author: Marin SJ, Coles R, Urry FM, McMillin GA.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Oct 15; 858(1-2):59-64. PubMed ID: 17881300.
    Abstract:
    Meconium has become the specimen of choice for determining fetal exposure to drugs of abuse, but its physical complexity can cause interferences from matrix effects. A new method to determine 9-carboxy-11-nor-Delta(9)-THC (9-THCA) and 11-hydroxy-Delta(9)-THC (11-OH-THC) using two-dimensional (2D) GC-MS was developed to reduce interferences and carryover. The method was validated using 70 spiked samples prepared in drug-free meconium and 46 residual patient specimens that were confirmed to contain cannabinoids. Ten patient specimens that failed to confirm due to interferences using the previous GC-MS method were analyzed using the new 2D method and 9-THCA was quantitated in all ten samples. The 2D GC-MS method improved chromatography which significantly reduced interferences and carryover when compared to the previous GC-MS method.
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