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  • Title: Role of bone marrow trephine biopsy in the diagnosis of marrow involvement in Hodgkin's disease.
    Author: Subramanian R, Basu D, Badhe B, Dutta TK.
    Journal: Indian J Pathol Microbiol; 2007 Jul; 50(3):640-3. PubMed ID: 17883170.
    Abstract:
    Bone marrow involvement in Hodgkin's disease alters the stage and hence the prognosis and treatment modality. Seventy-six patients of biopsy proven Hodgkin's disease in whom a bone marrow aspiration and biopsy were done simultaneously at the time of diagnosis were included in the study. Bone marrow involvement was seen in 14 (18%) cases. All 14 cases were diagnosed on biopsy. Only one aspirate was suspicious of involvement. Rest was either diluted (28%) or was normal (64%). Eleven patients were upstaged from stage I, II and III to stage IV. All patients had cytopenia of one or more cell line. Increased fibrosis, necrosis and a polymorphic cellular infiltrate were associated findings in the marrow. We wish to highlight the importance of bone marrow trephine biopsy over aspirate in staging even clinically early stage Hodgkin's disease.
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