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  • Title: Acute varicella infection mimics recurrent Hodgkin's disease on F-18 FDG PET/CT.
    Author: Sheehy N, Israel DA.
    Journal: Clin Nucl Med; 2007 Oct; 32(10):820-1. PubMed ID: 17885370.
    Abstract:
    We report a case where acute varicella infection, chickenpox, mimics the findings of recurrent Hodgkin disease on F-18 FDG PET/CT. A 28-year-old man with a history of Hodgkin disease in remission had fatigue, pyrexia, and a raised ESR. His F-18 FDG PET/CT, performed to exclude lymphoma recurrence, demonstrated FDG-avid lymphadenopathy and increased FDG uptake in his spleen. A day later he developed the generalized rash of acute varicella infection. This was managed with valacyclovir. Repeat F-18 FDG PET/CT done 1 month later showed no evidence of FDG-avid disease. In this patient the stimulation of an immune response by the acute viral infection mimics recurrent lymphoma.
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