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  • Title: [The results of using differentiated programs of therapy in acute lymphoblastic leukemia in adults].
    Author: Volkova MA, Perilov AA, Kaletin GI, Tupitsyn NN, Frenkel' MA, Fleĭshman EV.
    Journal: Ter Arkh; 1991; 63(7):109-11. PubMed ID: 1788786.
    Abstract:
    Results of the treatment of 30 adult patients with acute lymphoblastic leukemia are analyzed. Before the treatment was commenced, the patients were distributed into groups with a favourable, intermediate and unfavourable prognosis depending on the signs previously defined by the authors. In the phase of induction and consolidation of a remission, the treatment intensity in these groups varied. The rate of complete remissions (CR) reached 70% in the whole group; provided Ph-positive ALLs were excluded from the analysis, it was 75%, the median duration of the CR amounted to 21 months, the projected 4-year relapse-free survival was 41%. In the group of historic control (31 patients treated in accordance with the unified program), these indicators were 58 and 69%, 18 months, and 21%, respectively. All the differences appeared statistically insignificant. In spite of the total treatment intensification, the rate of lethal outcomes did not rise during remission induction.
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