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  • Title: [Anabolic action of prolactin on phosphatidylcholine metabolism in guinea pig adrenocorticocytes].
    Author: Sautin IuIu, Tron'ko ND, Kovzun EI, Mikosha AS.
    Journal: Ukr Biokhim Zh (1978); 1991; 63(5):73-8. PubMed ID: 1788877.
    Abstract:
    Isolated adrenocortical cells of guinea pigs whom injected with prolactin (PRL) during 3 days incorporated [3H] choline into phosphatidylcholine more intensively than those cells of animals in control. Labelling of intracellular pools of choline and phosphorylcholine remained unchanged, though a part of radioactivity represented by the water-soluble precursors decreased due to PRL influence. The rate of disappearance of labelled phosphatidylcholine in adrenocortical cells prelabelled with [3H] choline was lower in cells obtained from PRL-treated animals. The discharge of [3N] choline accumulated during prelabeling accelerated simultaneously. Rate of the phosphorylcholine radioactivity fall remained unchanged. The obtained data showed that prolonged influence of PRL caused a shift of the phosphatidylcholine metabolism to anabolism. That effect might be a part of the mechanism of proliferative PRL action in the adrenal cortex.
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