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  • Title: Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells.
    Author: Kapoor S, Marwaha R, Majumdar S, Ghosh S.
    Journal: Leuk Res; 2008 Apr; 32(4):559-67. PubMed ID: 17889364.
    Abstract:
    Malignant transformation is known to be associated with changes in cell surface carbohydrate-architecture, which can be detected by lectins. In the present study, Maackia amurensis agglutinin (MAA), specific for NeuNAcalpha(2-->3)Gal/GalNAc showed strong binding with lymphoblasts of children having acute lymphoblastic leukemia (ALL) as compared to cells from children with non-hematological disorders ("Controls"). MAA recognized a 66 kDa sialoglycoprotein present in membrane fraction of ALL cells. Moreover, MAA induced apoptosis in ALL cells was found to be reduced significantly in presence of GM2/IgG(MAA). Thus, MAA has a potential to be used as diagnostic and therapeutic agent in case of childhood-ALL.
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