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  • Title: Anthelmintic activity of paraherquamide in dogs.
    Author: Shoop WL, Eary CH, Michael BF, Haines HW, Seward RL.
    Journal: Vet Parasitol; 1991 Nov; 40(3-4):339-41. PubMed ID: 1788941.
    Abstract:
    Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei and Penicillium charlesii, was tested against the common gastrointestinal nematodes of dogs at a single oral dosage of 0.5, 1.0, or 2.0 mg kg-1. Efficacy was poor (less than 85%) against Ancylostoma caninum, Uncinaria stenocephala, Toxascaris leonina, Trichuris vulpis, and Strongyloides stercoralis at the low- and mid-dosage levels. At the high dosage level, good efficacy (91%) was observed only against S. stercoralis. Adverse reactions were observed in all dogs at every dosage level and included depression, ataxia, and protrusion of the nictitating membrane.
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