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  • Title: Effects of a plasmid-encoded qnrA1 determinant in Escherichia coli strains carrying chromosomal mutations in the acrAB efflux pump genes.
    Author: Jeong JY, Kim ES, Choi SH, Kwon HH, Lee SR, Lee SO, Kim MN, Woo JH, Kim YS.
    Journal: Diagn Microbiol Infect Dis; 2008 Jan; 60(1):105-7. PubMed ID: 17889488.
    Abstract:
    The qnrA1 gene was cloned into a plasmid vector and transformed into Escherichia coli strains carrying chromosomal mutations in the acrAB drug efflux system. In acrAB-deleted strains, and in strains overexpressing acrAB, viable qnrA conferred higher MIC levels (at least a 32-fold increase) for fluoroquinolones than were observed in the parent strains.
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