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  • Title: Turnover and intranuclear localization of 125I-insulin in Tetrahymena. An autoradiographic study.
    Author: Fülöp AK, Csaba G.
    Journal: Acta Morphol Hung; 1991; 39(2):71-7. PubMed ID: 1789147.
    Abstract:
    The unicellular Tetrahymena first internalized, then partly released the labelled insulin. Insulin-pretreated (imprinted) Tetrahymena cells behaved differently from non-pretreated cells, in that they retained a greater part of internalized insulin in the cytoplasm. Additional exposure to excessive non-labelled (cold) insulin caused a decrease in intracellular labelled insulin retention. Internalized insulin also entered the nucleus of Tetrahymena, where it was found in a heterochromatic localization.
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