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  • Title: Fast and controlled release of triamcinolone acetonide from extrusion-spheronization pellets based on mixtures of native starch with dextrin or waxy maize starch.
    Author: Sergio AP, Isabel de SF, José BM, Otero-Espinar FJ.
    Journal: Drug Dev Ind Pharm; 2007 Sep; 33(9):945-51. PubMed ID: 17891580.
    Abstract:
    Pellets composed chiefly of inexpensive starches allow modulation of the rate of release of the poorly soluble drug triamcinolone acetonide in media of pH 1.2-6.8. Wheat- or maize-starch-based pellets with 20% of white dextrin release the drug in vitro almost completely within 20 min, while maize-starch-based pellets with 5-35% of waxy maize starch sustain gradual release over periods of 9-12 hr or longer when prepared using appropriate amounts of granulation fluid.
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