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  • Title: Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity.
    Author: Ramírez JA, Bruttomesso AC, Michelini FM, Acebedo SL, Alché LE, Galagovsky LR.
    Journal: Bioorg Med Chem; 2007 Dec 15; 15(24):7538-44. PubMed ID: 17892941.
    Abstract:
    In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-alpha production by macrophages. A preliminary qualitative structure-activity relationship was established.
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