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  • Title: [The use of galanthamine in epidural anesthesia with trimecaine and fentanyl].
    Author: Ugol'nikov VA.
    Journal: Anesteziol Reanimatol; 1991; (6):50-2. PubMed ID: 1789488.
    Abstract:
    Analgesia and hemodynamic parameters during epidural anesthesia with trimecaine (2% solution) in combination with fentanyl (200 micrograms) have been studied in 56 patients aged 28-84 years. During premedication 34 patients were, in addition to atropine, dimedrol and relanium, administered galanthamine (15 mg); 22 patients were not given galanthamine. Fentanyl was administered with the first doses of the anesthetic. It has been established that premedication with galanthamine reduced the time of anesthesia onset by 19.6% and decreased the initial anesthetic dose by 10.7%. The initial period of anesthesia was characterized by a 23% increase in the number of cases with retained baseline BP level, a 1.6-fold decrease in the value of BP lowering, a 2.4-fold slowing of the time of hypotonic reaction development and a 31% shortening of the time of bradycardia onset.
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