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  • Title: [Effects of cholinergic antagonists in stress].
    Author: Nezhinskaia GI, Losev NA, Sapronov NS.
    Journal: Patol Fiziol Eksp Ter; 2007; (2):12-3. PubMed ID: 17899801.
    Abstract:
    Effects of methacine, hexamethonium and their combinations with neostigmine on activity of B-lymphocytes in various phases of immune response and development of stress ulcers induced in animals were studied. The drugs were found to modulate B-lymphocyte activity for 28 days and longer. By a water-immersion stress model it was shown that methacin is effective not only as m-cholinolytic but also as an immunoprophylactic drug reducing destructive changes in gastric mucosa. Injection of methacin 30 min before stress (block of m-cholinoreceptors) or 14 days before stress (maximal increase of B cell activity) results in 3-4-fold inhibition of ulcerogenesis in gastric mucosa.
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