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  • Title: Combinatorial Knoevenagel reactions.
    Author: Ryabukhin SV, Plaskon AS, Volochnyuk DM, Pipko SE, Shivanyuk AN, Tolmachev AA.
    Journal: J Comb Chem; 2007; 9(6):1073-8. PubMed ID: 17900167.
    Abstract:
    Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the Knoevenagel condensations of aromatic aldehydes with various methylene active compounds. High yields and a simple workup of target compounds enables the facile generation of combinatorial libraries comprising 11,000 compounds of high structural and functional diversity.
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