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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: The sensitivity and specificity of the 9-item Wearing-off Questionnaire.
    Author: Stacy MA, Murphy JM, Greeley DR, Stewart RM, Murck H, Meng X, COMPASS-I Study Investigators.
    Journal: Parkinsonism Relat Disord; 2008; 14(3):205-12. PubMed ID: 17900967.
    Abstract:
    OBJECTIVE: This multicenter, cross-sectional study was conducted to determine the sensitivity and specificity of a 9-item Wearing-off Questionnaire (WOQ-9) compared with assessment by a clinician. METHODS: Patients with a diagnosis of Parkinson's disease (PD) for 5 <or=years, and receiving stable antiparkinsonian therapy for >or=90 days, completed the WOQ-9 before independent evaluation by the physician. RESULTS: One hundred fifty-seven patients reported WO using the WOQ-9; only 79 had been previously diagnosed with WO by a physician. The most frequent items used by physicians to diagnose WO included type of symptoms (69.6%), symptom response (63.3%), and timing of symptom response (58.2%) to medication. Physician assessment of WO and WOQ-9 results corresponded in 76 of 79 cases; physicians disagreed with WO identification in 81 of 157 cases. Sensitivity of the WOQ-9 was 96.2% and specificity was 40.9%. CONCLUSION: The WOQ-9 is a useful screening tool to aid diagnosis of WO in PD patients.
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