These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Changes in CMDP and DPOAE during acute increased inner ear pressure in the guinea pig.
    Author: Valk WL, Wit HP, Albers FW.
    Journal: Eur Arch Otorhinolaryngol; 2008 Mar; 265(3):287-92. PubMed ID: 17901968.
    Abstract:
    During and after an increase of inner ear pressure, induced by injection of artificial perilymph, the 2f1 - f2 and f2 - f1 distortion products (DPs) in cochlear microphonics (CM) and otoacoustic emissions (OAE) were recorded in the guinea pig. An inner pressure increase of approximately 600 Pa gave only small changes in CMDP and DPOAE. Along with a decrease in f1 amplitude, a small decrease in amplitude of the 2f1 - f2 and a small increase in the f2 - f1 were measured in CM. This matches a shift from a symmetrical position of the operating point for hair cell transduction, leading to an increase in even-order distortion and a decrease in odd-order distortion. Similar, a decrease in 2f1 - f2 DPOAE was expected. This might be the case at the generation sites but this effect was then more than compensated for by a better middle ear transfer, accounting for the increase of 0.4 dB of the 2f1 - f2 DPOAE amplitude. In conclusion, changes of overall inner ear fluid pressure have minor effects on cochlear function. This is a relevant finding for further understanding of diseases with changed inner ear fluid volumes, as Ménière's.
    [Abstract] [Full Text] [Related] [New Search]