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  • Title: Simple copper salt-catalyzed N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl halides.
    Author: Zhu L, Guo P, Li G, Lan J, Xie R, You J.
    Journal: J Org Chem; 2007 Oct 26; 72(22):8535-8. PubMed ID: 17902694.
    Abstract:
    Relatively mild and highly efficient CuI-catalyzed N-arylation procedures for nitrogen-containing heterocycles (e.g., imidazoles, benzimidazoles, pyrroles, pyrazoles, indoles, triazoles, etc.) with aryl and heteroaryl halides have been developed. The protocols can be performed easily and tolerate a number of functional groups, such as ester, nitrile, nitro, ketone, free hydroxyl, and free primary amine on the aryl halide.
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