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  • Title: Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype.
    Author: Scherbik SV, Kluetzman K, Perelygin AA, Brinton MA.
    Journal: Virology; 2007 Nov 25; 368(2):232-7. PubMed ID: 17904183.
    Abstract:
    Inheritance patterns in mice suggested that resistance to flavivirus-induced disease was conferred by a single autosomal dominant allele (Flv(r)). A positional cloning strategy followed by comparison of Flv interval gene sequences from congenic resistant C3H.PRI-Flv(r) and susceptible C3H/He mouse strains identified the 2'-5'-oligoadenylate synthetase 1b (Oas1b) gene as Flv. However, since these mouse strains differ by a 31 cM region, the possible involvement of differences in other linked genes in the resistant phenotype could not be absolutely ruled out. Knock-in of the Oas1b resistance allele into a susceptible mouse strain produced mice with the flavivirus resistance phenotype, confirming that this phenotype is mediated by a single gene.
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