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  • Title: Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors.
    Author: Dwyer MP, Paruch K, Alvarez C, Doll RJ, Keertikar K, Duca J, Fischmann TO, Hruza A, Madison V, Lees E, Parry D, Seghezzi W, Sgambellone N, Shanahan F, Wiswell D, Guzi TJ.
    Journal: Bioorg Med Chem Lett; 2007 Nov 15; 17(22):6216-9. PubMed ID: 17904366.
    Abstract:
    A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the in-vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors.
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