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  • Title: T cell therapy of Epstein-Barr virus and adenovirus infections after hemopoietic stem cell transplant.
    Author: Comoli P, Basso S, Labirio M, Baldanti F, Maccario R, Locatelli F.
    Journal: Blood Cells Mol Dis; 2008; 40(1):68-70. PubMed ID: 17904879.
    Abstract:
    Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD) and adenovirus (AdV)-related pathologies are life-threatening complications of immunosuppression in recipients of hematopoietic stem cell transplantation (HSCT). In certain cohorts (unrelated and haploidentical donor HSCT, T-cell-depleted allograft), the risk of developing these complications is higher. Here we describe the impact of T cell therapy, within programs of specific routine surveillance and preemptive treatment, on the course of EBV infection, and development of related disease, in pediatric recipients of T-cell-depleted, HLA-haploidentical HSCT. Future prospectives include the transfer of this technology to treat AdV-related complications following HSCT.
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