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  • Title: HCV research and anti-HCV drug discovery: toward the next generation.
    Author: Wakita T.
    Journal: Adv Drug Deliv Rev; 2007 Oct 10; 59(12):1196-9. PubMed ID: 17905463.
    Abstract:
    Hepatitis C virus (HCV) causes persistent infection and induces chronic hepatitis, liver cirrhosis and finally hepatocellular carcinoma. Current therapies for HCV infection have not been satisfactory, and more effective anti-viral treatments are needed. In this regard, detailed analysis of HCV has been hampered by a lack of appropriate viral culture systems and small animal models of infection. However, rapid progress in HCV research has recently been achieved, such as a subgenomic replicon system, a viral culture system using JFH-1 clone and the Alb-uPA/SCID mouse transplanted with human liver cells. Such progress will propel HCV research and anti-HCV drug discovery toward the next generation.
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