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  • Title: [Immunologic tolerance of anti-Abeta antibody in the sera of AD patients].
    Author: Yang ZY, Wang HQ, Xu J, Xie Y, Yuan QF, Yao ZB.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2007 Oct; 23(10):929-31. PubMed ID: 17908502.
    Abstract:
    AIM: To characterize anti-amyloid-beta antibodies in the sera of Alzheimer's disease(AD) patients. METHODS: A special tissue amyloid plaque immunoreactivity (TAPIR) examinations of brains of Tg2576 mice was carried out. Abeta(42)-GST fusion protein was detected by Western blot. and then the survival rate of PC12 cells incubated with the sera and Abeta(42) was measured by MTT assay. RESULTS: The sera in AD patients could not recognize the senile plaque in the brains of Tg2576 mice and could not cross-react with Abeta(42)-GST fusion protein. Furthermore, PC12 cells incubated with the sera from AD patients presented the decreased A value compared with the healthy elderly(P<0.01). CONCLUSION: The anti-Abeta antibodies in the sera of AD patients may have immunologic tolerance to amyloid peptide.
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