These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes.
    Author: Mullin BR, Aloj SM, Fishman PH, Lee G, Kohn LD, Brady RO.
    Journal: Proc Natl Acad Sci U S A; 1976 May; 73(5):1679-83. PubMed ID: 179095.
    Abstract:
    Unlabeled cholera toxin inhibits [125I]thyrotropin binding to thyrotropin receptors on thyroid plasma membranes. Maximal inhibition by cholera toxin does not exceed 40%, whereas unalbeled thyrotropin completely inhibits [125I]thyrotropin binding to these same membranes. Kinetic analyses of the binding data are compatible with the view that the cholera toxin decreases the number of receptor sites available to thyrotropin and that the mechanism by which the cholera toxin inhibits [125I]thyrotropin binding to these receptor sites involves both competitive and noncompetitive elements.
    [Abstract] [Full Text] [Related] [New Search]