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  • Title: Evolution of some variable-number tandem repeat loci among a group of Beijing strains of Mycobacterium tuberculosis.
    Author: Billamas P, Smittipat N, Juthayothin T, Thong-On A, Yamada N, Yanai H, Palittapongarnpim P.
    Journal: Tuberculosis (Edinb); 2007 Nov; 87(6):498-501. PubMed ID: 17910937.
    Abstract:
    The patterns of variable-number tandem repeats (VNTR) genotypes of a clonal group of Mycobacterium tuberculosis Beijing isolates with very similar IS6110-restriction fragment length polymorphism (RFLP) patterns were studied. Differences between VNTR were mostly by a single repeat unit. However, a multiple-unit change also occurred. This suggests that a mechanism other than the slipped-strand mispairing might be responsible for the instability of VNTR in M. tuberculosis as well. This finding is useful for inferring phylogenetics of M. tuberculosis based on the VNTR genotypes.
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