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  • Title: Lung injury in acute experimental pancreatitis in rats. II. Functional studies.
    Author: Feddersen CO, Willemer S, Karges W, Püchner A, Adler G, Wichert PV.
    Journal: Int J Pancreatol; 1991 May; 8(4):323-31. PubMed ID: 1791318.
    Abstract:
    In this study we report the functional changes in isolated perfused lungs from rats with cerulein-induced experimental pancreatitis. Rat lungs isolated immediately after the cerulein infusion demonstrated decreased pressor responses to angiotensin II (A II) and acute hypoxia (FIO2: 0.0). The lung wet- to dry-weight ratio was increased, as was the lung-leak index, consistent with high-permeability edema formation in the lung. Neither saline-solution infusion for 12 h nor perfusion with cerulein of rat lungs isolated from untreated animals caused lung injury or functional alterations. The changes in pulmonary vascular reactivity were normalized 48-72 h after induction of pancreatitis. In conclusion, we describe an animal model of pancreatitis and reversible, ARDS-like lung injury.
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