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  • Title: Increased sarcoma virus RNA in cells transformed by leukemia viruses: model for leukemogenesis.
    Author: Peebles PT, Scolnick EM, Howk RS.
    Journal: Science; 1976 Jun 11; 192(4244):1143-5. PubMed ID: 179144.
    Abstract:
    A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.
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