These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Anion-exchange chromatography-electrospray ionization mass spectrometry method development for the environmental analysis of aliphatic polyhydroxy carboxylic acids.
    Author: Meyer A, Höffler S, Fischer K.
    Journal: J Chromatogr A; 2007 Nov 02; 1170(1-2):62-72. PubMed ID: 17915229.
    Abstract:
    For environmental analytical purposes, an anion-exchange chromatography-electrospray ionization MS method was developed enabling the identification and quantification of 18 aliphatic (poly)hydroxy (poly)carboxylic acids including sugar and uronic acids. The initially incomplete separation could be partially improved for specific analyte combinations adding borate, the zwitter ionic MES, or an alkylglycoside to the NaOH gradient supplied with the Dionex IonPac AS-11 HC column. Despite the incomplete separation, reproducible and sensitive identification and quantification is possible with MS detection in the selected ion-monitoring mode. Applying an internal standard for the compensation of the sensitivity drift of the detector, linear calibration functions were calculated for all analytes. Limits of detection spanned between 18 and 71 microgL(-1) which could be further improved for some more hydrophobic analytes by post-column addition of MeOH.
    [Abstract] [Full Text] [Related] [New Search]