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  • Title: Vilsmeier-Haack reactions of 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans toward the synthesis of highly substituted pyridin-2(1H)-ones.
    Author: Xiang D, Yang Y, Zhang R, Liang Y, Pan W, Huang J, Dong D.
    Journal: J Org Chem; 2007 Oct 26; 72(22):8593-6. PubMed ID: 17915930.
    Abstract:
    A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones was developed via Vilsmeier-Haack reactions of readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophilic cyclization reactions is proposed.
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