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  • Title: [Inhibition of Sorbaria sorbifolia on proliferarion of hepatoma HepG-2 cell line].
    Author: Zhang XW, Cui CX, Chen LY.
    Journal: Zhong Yao Cai; 2007 Jun; 30(6):681-4. PubMed ID: 17918440.
    Abstract:
    OBJECTIVE: To investigate the inhibition of Sorbaria sorbifolia on proliferation hepatoma HepG-2 cells, and to explore the antineoplastic mechanism of Sorbaria sorbifolia. METHODS: MTT assay was used to examine the effect of Sorbaria sorbifolia on the proliferation of HepG-2 cell and flow cytometry was used for the cell cycle distribution. Apoptosis of HepG-2 cell was investigated further by means of inverted microscope, HE staining, transmission electron microscopy and expression of apoptosis-associated gene bcl-2 and p53 were determined by immunohistochemical method. RESULTS: Sorbaria sorbifolia inhibited the proliferation of HepG-2 cell and the effects were in a time-and-concentration dependent manner. Sorbaria sorbifolia could also induce apoptosis, the G2/M phase was arrested and the ratio of apoptosis was significantly difference with that of control group, respectively. The expressions of apoptosis-associated gene bcl-2 and p53 had changed significantly, respectively. CONCLUSION: Sorbaria sorbifolia inhibits proliferation of HepG-2 cells via induction of apoptosis and cell cycle arrest.
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