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  • Title: The microcirculation and essential hypertension.
    Author: Draaijer P, Le Noble JL, Leunissen KM, Struyker-Boudier HA.
    Journal: Neth J Med; 1991 Oct; 39(3-4):158-69. PubMed ID: 1791878.
    Abstract:
    Essential hypertension is characterized by a progressive increase of the mean arterial pressure paralleled by a concomitant increase in the total peripheral resistance. This elevated resistance is the consequence of (a) a decreased internal diameter, (b) an increased wall-to-lumen ratio or (c) a decreased number of small arteries or arterioles. A considerable part of the elevated vascular resistance is determined at the microcirculatory level. This paper reviews the studies performed to unravel the resistance-elevating mechanisms in the microvasculature of different tissues. Furthermore the possible role of the microcirculation in the pathogenesis of essential hypertension is discussed.
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