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  • Title: Cytotoxic lignans from the stem bark of Magnolia officinalis.
    Author: Youn UJ, Chen QC, Jin WY, Lee IS, Kim HJ, Lee JP, Chang MJ, Min BS, Bae KH.
    Journal: J Nat Prod; 2007 Oct; 70(10):1687-9. PubMed ID: 17918910.
    Abstract:
    Three new lignans, 4'-methoxymagndialdehyde ( 1), 4'-methoxymagnaldehyde B ( 2), and 4'-methoxymagnaldehyde E ( 3), were isolated from hexane- and EtOAc-soluble fractions of the stem bark of Magnolia officinalis, together with eight known compounds ( 4- 11). The structures of compounds 1- 3 were determined on the basis of spectroscopic and physicochemical data analysis. Compounds 1- 11 were tested in vitro for their cytotoxic activity against the K562, HeLa, and A549 cancer cell lines. Among the compounds tested, compound 1 showed the most potent cytotoxic activity against these cancer cell lines, with IC50 values of 3.9, 1.5, and 3.7 microg/mL, respectively.
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