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  • Title: Alpha-tocopherol supports the survival and neurite extension of neurons cultured from various regions of fetal rat brain.
    Author: Nakajima M, Kashiwagi K, Hayashi Y, Saito M, Kawashima T, Furukawa S, Kobayashi K.
    Journal: Neurosci Lett; 1991 Nov 25; 133(1):49-52. PubMed ID: 1791998.
    Abstract:
    The effects of alpha-tocopherol on neurons of fetal rat brain were studied in tissue culture. alpha-Tocopherol supported the survival and enhanced neurite extension of neurons cultured from cerebral cortex, hippocampus, striatum, and septum. The survival effect was observed at concentrations of 10(-9) to 10(-6) M. More than 60% of the cortical neurons could survive for 9 days at 10(-7) or 10(-6) M alpha-tocopherol, whereas almost all neurons died within 2 days in its absence. These results suggest that alpha-tocopherol may be involved in mechanisms regulating neuronal survival and neurite formation in the central nervous system, and indicate that alpha-tocopherol may be an excellent reagent to facilitate neuronal survival in culture.
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