These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis.
    Author: Thompson AR, Drenos F, Hafez H, Humphries SE.
    Journal: Eur J Vasc Endovasc Surg; 2008 Jan; 35(1):19-30. PubMed ID: 17920311.
    Abstract:
    BACKGROUND: Candidate gene analysis has been frequently used in attempts to understand the pathological processes involved in many aspects of AAA disease. METHODS: This paper sets out a systems approach to reviewing AAA candidate gene analysis studies, whilst, explaining the key principles and design limitations of this universally applied technique. In addition we have performed a meta-analysis of six gene polymorphisms (ACE I/D, MTHFR+677C>T, MMP9-1562C>T, Il-1Beta/3953C>T, eNOS 4a/4b & TIMP1/+434C>T) reported in multiple case control studies. RESULTS AND CONCLUSIONS: Three of these polymorphisms were associated with a significant risk of AAA, ACE RR 1.33 [95% CI 1.20-1.48], MTHFR RR 1.14 [1.08-1.21] and MMP9 RR 1.09 [1.01-1.18]. These differences have been previously reported as equivocal, within a context of contradictory studies and as such this meta-analysis provides new evidence for their involvement in AAA disease. The plausibility of these findings is discussed within the context of a systems approach to the pathology of AAA disease.
    [Abstract] [Full Text] [Related] [New Search]