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  • Title: Deficiency in monocyte chemoattractant protein-1 modifies lipid and glucose metabolism.
    Author: Rull A, Escolà-Gil JC, Julve J, Rotllan N, Calpe-Berdiel L, Coll B, Aragonès G, Marsillach J, Alonso-Villaverde C, Camps J, Blanco-Vaca F, Joven J.
    Journal: Exp Mol Pathol; 2007 Dec; 83(3):361-6. PubMed ID: 17920586.
    Abstract:
    We describe the effect of MCP-1 deficiency in mice rendered hyperlipemic by the concomitant ablation of the LDL receptor. The MCP-1(-/-)LDLr(-/-) mice in comparison with LDLr(-/-) mice showed a decreased lipoprotein clearance, derangements in free fatty acids delivery and less glucose tolerance when fed a regular chow, and they showed a partial resistance to alterations in glucose and lipid metabolism induced by dietary fat and cholesterol. They also were less prone to the development of diet-induced obesity. Our results suggest that the role of MCP-1 in metabolism is relevant and that, although new hidden complexities are evident, the function of MCP-1/CCL2 extends far beyond the monocyte chemoattractant effect. Therefore, the regulatory mechanisms influenced by MCP-1 should be fully ascertained to understand the metabolic consequences of inflammation and before considering MCP-1 as a therapeutic target.
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