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  • Title: Pyrene-perylene as a FRET pair coupled to the N2'-functionality of 2'-amino-LNA.
    Author: Lindegaard D, Madsen AS, Astakhova IV, Malakhov AD, Babu BR, Korshun VA, Wengel J.
    Journal: Bioorg Med Chem; 2008 Jan 01; 16(1):94-9. PubMed ID: 17920888.
    Abstract:
    Detection of nucleic acid hybridization via fluorescence resonance energy transfer (FRET) using pyren-1-ylmethyl and perylen-3-ylmethyl N2'-functionalized 2'-amino-LNA nucleosides incorporated into oligonucleotides exhibited a clear distance dependence of the FRET efficiency, ranging from below 10% when the fluorophores were approximately 40A apart to approximately 90% when the fluorophores were in close proximity.
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