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  • Title: Human herpesvirus (HHV)-6 and HHV-7 infections in pregnant women.
    Author: Caserta MT, Hall CB, Schnabel K, Lofthus G, McDermott MP.
    Journal: J Infect Dis; 2007 Nov 01; 196(9):1296-303. PubMed ID: 17922393.
    Abstract:
    BACKGROUND: Both intrauterine and sexual transmission of human herpesvirus (HHV)-6 and HHV-7 have been suggested, and congenital HHV-6 infection does occur. We prospectively studied HHV-6 and HHV-7 at multiple sites in pregnant women to determine the characteristics of these viruses at repeated time points. METHODS: Peripheral blood mononuclear cells (PBMCs), cervical secretions, placenta, and cord blood were tested by nested polymerase chain reaction (PCR) and reverse-transcriptase PCR for HHV-6 and HHV-7 and by quantitative PCR for HHV-6. A control group of women was also studied. RESULTS: We enrolled 104 pregnant and 31 control women. HHV-7 DNA was detected more frequently in PBMCs from pregnant women (66.9%) than HHV-6 DNA (22.2%; P<.0001), but both were found at low rates in cervical swabs (HHV-7 vs. HHV-6 DNA, 3.0% vs. 7.5%; P=.19). Pregnant women with HHV-6 DNA present in cervical swabs had a greater odds of having HHV-6 DNA present in the blood than did pregnant women with negative cervical swabs (odds ratio, 12.9; P=.0009). HHV-6 reactivation or reinfection was suggested in 17% of pregnant women. One placental sample had active HHV-6 replication. CONCLUSIONS: Detection of HHV-6 DNA in cervical secretions is associated with HHV-6 DNA in PBMC samples. Active placental infection along with congenital HHV-6 infection was identified.
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