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  • Title: Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives.
    Author: Khrizman A, Slack RD, Remsing RC, Little S, Yardley V, Moyna G.
    Journal: Arch Pharm (Weinheim); 2007 Nov; 340(11):569-76. PubMed ID: 17924365.
    Abstract:
    The synthesis and in vitro antiparasitic activity of twenty-seven novel diazabicycles based on tropolone ethers is presented. The compounds can be readily prepared by means of a high-yielding hetero Diels-Alder reaction using simple and readily available starting materials. Several of the new diazabicycles have in vitro activities against Trypanosoma cruzi, Leishmania donovani, Trypanosoma brucei rhodesiense, and chloroquine-resistant Plasmodium falciparum that are comparable or superior to those of currently employed protozoocidal agents.
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