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  • Title: Tris buffer (THAM). An appraisal of its physiologic effects and clinical usefulness.
    Author: Bleich HL, Schwartz WB.
    Journal: N Engl J Med; 1966 Apr 07; 274(14):782-7. PubMed ID: 17926886.
    Abstract:
    It has been the purpose of this discussion to review critically the physiologic considerations and clinical evidence regarding the use of Tris buffer in the treatment of acid-base disorders. It is concluded that there is little current evidence, theoretical, experimental, or clinical, to support the view that Tris has a significant therapeutic role. Some possible exceptions to this general conclusion are considered.
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