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  • Title: Menin is required in cranial neural crest for palatogenesis and perinatal viability.
    Author: Engleka KA, Wu M, Zhang M, Antonucci NB, Epstein JA.
    Journal: Dev Biol; 2007 Nov 15; 311(2):524-37. PubMed ID: 17927973.
    Abstract:
    Menin is a nuclear protein encoded by a tumor suppressor gene that is mutated in humans with multiple endocrine neoplasia type 1 (MEN1). Menin functions as a component of a histone methyltransferase complex that regulates expression of target genes including the cell cycle inhibitor p27(kip1). Here, we show that menin plays a previously unappreciated and critical role in cranial neural crest. Tissue-specific inactivation of menin in Pax3- or Wnt1-expressing neural crest cells leads to perinatal death, cleft palate and other cranial bone defects, which are associated with a decrease in p27(kip1) expression. Deletion of menin in Pax3-expressing somite precursors also produces patterning defects of rib formation. Thus, menin functions in vivo during osteogenesis and is required for palatogenesis, skeletal rib formation and perinatal viability.
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