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  • Title: Imprint cytology improves accuracy of computed tomography-guided percutaneous transthoracic needle biopsy.
    Author: Chang YC, Yu CJ, Lee WJ, Kuo SH, Hsiao CH, Jan IS, Hu FC, Liu HM, Chan WK, Yang PC.
    Journal: Eur Respir J; 2008 Jan; 31(1):54-61. PubMed ID: 17928311.
    Abstract:
    The aim of the present study was to investigate whether imprint cytology can improve the diagnostic accuracy of computed tomography-guided transthoracic core biopsy. Between October 1997 and June 2004, thoracic lesions in 622 patients underwent biopsy using 19-gauge coaxial guiding needles and 20-gauge biopsy needles under computed tomography guidance. Touch imprint cytology and histopathology were performed for all biopsy specimens. Of these lesions, 431 (74.1%) were diagnosed as malignant, 151 (25.9%) as benign and 40 (6%) as nondiagnostic. Imprint cytology plus histology shows an improved diagnostic accuracy of 96.4% compared with that of imprint cytology alone (92.3%) or histopathology alone (93.0%). Procedure-related complications requiring further treatment occurred in eight (1.4%) patients. In conclusion, imprint cytology combined with histopathology can improve the diagnostic accuracy of computed tomography-guided transthoracic needle biopsy.
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