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  • Title: No potassium, no acid: K+ channels and gastric acid secretion.
    Author: Heitzmann D, Warth R.
    Journal: Physiology (Bethesda); 2007 Oct; 22():335-41. PubMed ID: 17928547.
    Abstract:
    The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.
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