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  • Title: Efficacy of once weekly erythropoietin therapy in children on continuous ambulatory peritoneal dialysis.
    Author: Hisano S, Kaku Y, Ueda K, Onoyama K.
    Journal: Acta Paediatr Jpn; 1991 Aug; 33(4):450-4. PubMed ID: 1792903.
    Abstract:
    The efficacy of recombinant human erythropoietin (rHuEPO) on 10 anemic children undergoing continuous ambulatory peritoneal dialysis (CAPD) was evaluated. A mean dose of 93 U/kg of rHuEPO was given once a week for 24 weeks, either intravenously to 5 children or subcutaneously to the other 5. Anemia improved in all children by this therapy. The mean hemoglobin and hematocrit levels increased gradually but significantly from 6.9 g/dl and 20.2% to 9.4 g/dl and 30.1%, respectively, at the end of the study. Elevation of blood pressure or other side effects were not noted in any patient. The present study indicates that the once-a-week injection of rHuEPO by the intravenous or subcutaneous route is effective in children undergoing CAPD.
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