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  • Title: Depression and risk of cardiovascular diseases among males aged 25-64 (WHO MONICA--psychosocial).
    Author: Gromova HA, Gafarov VV, Gagulin IV.
    Journal: Alaska Med; 2007; 49(2 Suppl):255-8. PubMed ID: 17929644.
    Abstract:
    OBJECTIVE: To study the influence of depression on risk of cardiovascular diseases development during 10 years in non-organized male population aged 25-64. STUDY DESIGN AND METHODS: Within the framework of the MONICA--psychosocial program a representative sample of 657 men 25-64 years old (1994 year) was examined. Depression was measured at baseline with the use of the MONICA--psychosocial Interview Depression scale. The incidence of new cases of AH, MI and stroke was revealed in the WHO "Registry MI" and "Registry stroke" 10-year follow-up. Cox is a proportional regression model that was used for estimation of RR. RESULTS: The proportion of depression in the cohort of men with AH was 28.9%, with MI--65.8% and of men with stroke 70.6%. The relative risk of development of AH, MI, stroke during the first five years of supervision in a group with the high level of depression as compared to those in whom depression was not observed was 6.7 times (p < 0.01), 2.26 times (p < 0.05), 6.4 times higher (p < 0.01), respectively. Within 10 years, the risk of development of cardiovascular diseases in men with high level of depression was: for AH--RR = 4.2; for MI--RR = 2.4; and stroke--RR = 5.2 (p < 0.05 comparing to those without it. CONCLUSION: Depression is a predictor of cardiovascular diseases in middle-aged men.
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