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  • Title: Familial alloimmune neutropenia of NA-2 specificity.
    Author: Ríos E, Heresi G, Arevalo M.
    Journal: Am J Pediatr Hematol Oncol; 1991; 13(3):296-9. PubMed ID: 1793155.
    Abstract:
    Three siblings with alloimmune neonatal neutropenia are presented. An immunoglobulin G (IgG) antineutrophil antibody specific for NA-2 antigen was demonstrated in maternal serum and in both of the three affected infants who were studied as neonates. The mother's neutrophils were negative for NA-2 antigen. The father and all four children, including the three known to be affected, had neutrophils that expressed NA-2 antigen. One patient studied sequentially demonstrated an inverse relationship between the antineutrophil antibody titer and the absolute neutrophil count. Exchange transfusions did not appear to benefit two of the infants.
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