These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Suspension of Fe(3)O(4) nanoparticles stabilized by chitosan and o-carboxymethylchitosan.
    Author: Zhu A, Yuan L, Liao T.
    Journal: Int J Pharm; 2008 Feb 28; 350(1-2):361-8. PubMed ID: 17931808.
    Abstract:
    In this study, a well-dispersed suspension of superparamagnetic Fe(3)O(4) nanoparticles was stabilized by chitosan (CS) and o-carboxymethylchitosan (OCMCS), respectively. The resulting magnetic Fe(3)O(4) nanoparticles were characterized by dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscope (TEM), zeta-potential measurement and vibrating sample magnetometry (VSM). TEM results demonstrated a spherical or ellipsoidal morphology with an average diameter of 14-20nm. The adsorbed layer of CS and OCMCS on the magnetite surface was confirmed by FTIR. XRD illustrated that the resulting magnetic nanoparticles have a spinel structure and lastly VSM results showed the modified magnetic Fe(3)O(4) nanoparticles were superparamagnetic. The adsorption mechanism of CS and OCMCS onto the surface of Fe(3)O(4) nanoparticles is believed to be the electrostatic and coordination interactions, respectively. The mechanisms of both CS and OCMCS stabilizing the suspension of Fe(3)O(4) nanoparticles were supposed electrostatic repulsion. These well-dispersed superparamagnetic Fe(3)O(4) nanoparticles stabilized by the biocompatible CS or OCMCS dispersant should have potential applications in biotechnology fields.
    [Abstract] [Full Text] [Related] [New Search]